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Methods A targeted literature search of experimental and clinical studies was performed, focusing on angiogenesis-related mechanisms in neurodegeneration and the effects of antiangiogenic compounds on neuronal and vascular function

Vial duration A 15 mg vial covers ~11 days at 4 IU/day and ~28 days at the lower 1.5 IU/day end fitting the 28-day reconstituted-use window

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